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Raffaella Tonini

Senior Researcher Tenured - Principal Investigator
Neuromodulation of Cortical and Subcortical Circuits
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Biografia

To adapt to an ever-changing environment and to reach specific goals, the brain needs to learn to choose between different behavioral options. This neuronal processing is influenced by the activity of neuromodulatory systems that can report selective perceptual and motivational information over multiple timescales. Neuromodulators act through specialized receptors localized on anatomically different pathways to shape the activity of neurons as well as the strength and plasticity of their synapses.  However, we have a limited mechanistic understanding of how the temporal coding of neuromodulatory signals affects the interactions between brain regions for perception and reward to implement neuronal computations.

Our aim is to resolve the spatiotemporal dynamic of behaviorally relevant neuromodulatory signals at cellular resolution by using new tools for probing, analyzing, and engineering  micro- and macrocircuits of the brain.  

All Publications
2023
RAIS C., BARILE S., PELLOUX Y., LI Y., TONINI R.
Dopamine and serotonin interactions within the Dorsal Raphe Nucleus-Central Amygdala circuit in the regulation of anxiety-related behavioral responses.
Annual Meeting of the Society for Neuroscience 2023
Abstract Report Conference
2023
LONGARETTI A., MANGONI D., PAGET-BLANC V., BOENDER A., PELLOUX Y., NAVA L., VEGGI M. F., LAU P., TARTAGLIA G., GUSTINCICH S., TONINI R.
LINE-1 long non-coding RNAs at striatal circuits contribute to the transition from flexible to inflexible behavioral control
Annual Meeting of the Society for Neuroscience 2023
Abstract Report Conference
2023
NAVA L., PELLOUX Y., BONTEMPI L., LOCARNO A., BARSOTTI N., PASQUALETTI M., LI Y., TONINI R.
Monoaminergic modulation of the Dorsal Raphe Nucleus shapes the momentary release of serotonin at Dorsal Striatum-Amygdala circuits.
Annual Meeting of the Society for Neuroscience 2023
Abstract Report Conference
2023
Indrigo M., Morella I., Orellana D., d'Isa R., Papale A., Parra R., Gurgone A., Lecca D., Cavaccini A., Tigaret C. M., Cagnotto A., Jones K., Brooks S., Ratto G. M., Allen N. D., Lelos M. J., Middei S., Giustetto M., Carta A. R., Tonini R., Salmona M., Hall J., Thomas K., Brambilla R., Fasano S.
Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2
EMBO Molecular Medicine
2023
Boi L., Johansson Y., Tonini R., Moratalla R., Fisone G., Silberberg G.
Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for Parkinson’s disease
eLife
Article Journal