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Stefano Gustincich

Senior Researcher - Research Director
Deputy Director for Life Sciences - Director of Neuroscience and Brain Technologies Department

Contacts

Via Morego 30 Genova 16163
+39 010 71781 447

About

Stefano Gustincich is Deputy Director for Life Science and Director of the Department of Neuroscience and Brain Technologies at the Istituto Italiano di Tecnologia (IIT), Genova, Italy. He is part-time Full Professor in Applied Biology at the International School for Advanced Studies (SISSA), Trieste.

After his training in Biology, he obtained his PhD degree in Molecular Genetics & Biotechnology at SISSA, Trieste. In 1993, he was awarded a long-term EMBO fellowship to join the Department of Neurobiology of Harvard Medical School, Boston (USA) where in 1998 he was appointed Instructor in Neurobiology. In 2003 he was granted the “Career Developmental Award” by “The Giovanni Armenise-Harvard Foundation” to found the Laboratory of Neurogenomics at SISSA where he became Associate Professor. In 2011 he was awarded the National Prize for Innovation in Biotechnology.

He has been part of the FANTOM consortium, a joint international effort led by the Japanese research institution RIKEN, to study the mammalian transcriptome. He has coordinated a large international consortium (DOPAMINET) focused on the molecular networks of dopaminergic neurons.

He wrote the masterplan for the Center of Neurogenomics at the Human Technopole, a new genomic research center in Milano, Italy.

His research interests concern the biology of the non-coding portion of the genome, the so-called “Junk DNA”. He recently discovered the SINEUPs, a new functional class of antisense long noncoding RNAs able to increase translation of their sense gene. He is the co-founder of TransSINE Technologies, a RIKEN Venture, Yokohama, Japan.

 

 

Selected Publications

 

Scientific Publications

 

Since the beginning of my scientific career, I published 96 peer-reviewed research articles and reviews with a total IF of 815, an average IF of 8.5, a h Index of 36 and more than 11000 citations (Google Scholar, May 2017).

 

 

Research article publications

 

1.      Codrich M, Bertuzzi M, Russo R, Francescatto M, Espinoza S, Zentilin L, Giacca M, Cesselli D, Beltrami AP, Ascenzi P, Zucchelli S, Persichetti F, Leanza G, Gustincich S. (2017). Neuronal hemoglobin affects dopaminergic cells’ response to stress. Cell Death Dis. 5;8(1):e2538. IF: 5.3.

2.      Nuzzo MT, Fiocchetti M, Totta P, Melone MA, Cardinale A, Fusco FR, Gustincich S, Persichetti F, Ascenzi P, Marino M. (2016). Huntingtin polyQ mutation impairs the 17-estradiol/neuroglobin pathways devoted to neuron survival. Mol Neurobiol. Epub ahead of print. IF: 5.1.

3.      Schein A, Zucchelli S, Kauppinen S, Gustincich S, Carninci P. (2016). Identification of antisense long noncoding RNAs that function as SINEUPs in human cells. Sci Rep 6:33605. IF: 5.228.

4.      Marcuzzi F, Zucchelli S, Bertuzzi M, Santoro C, Tell G, Carninci P, Gustincich S. (2016). Isoforms of the Erythropoietin Receptor in dopaminergic neurons of the Substantia Nigra. J Neurochem 4:596. IF: 3.842.

5.      Ferrer I, Garcia-Esparcia P, Carmona M, Carro E, Aronica E, Kovacs GG, Grison A, Gustincich S. (2016). Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease. Front Aging Neurosci 8:163. IF: 4.348.

6.      Indrieri A, Grimaldi C, Zucchelli S, Tammaro R, Gustincich S, Franco B. (2016). Synthetic long non-coding RNAs [SINEUPs] rescue defective gene expression in vivo. Sci Rep 6:27315. IF: 5.228.

7.      Agostoni E, Michelazzi S, Maurutto M, Carnemolla A, Ciani Y, Vatta P, Roncaglia P, Zucchelli S, Leanza G, Mantovani F, Gustincich S, Santoro C, Piazza S, Del Sal G, Persichetti F. (2016). Effects of Pin1 Loss in HdhQ111 Knock-in Mice. Front Cell Neurosci 10:110. IF: 4.609.

8.      Patrucco L, Peano C, Chiesa A, Guida F, Luisi I, Boria I, Mignone F, De Bellis G, Zucchelli S, Gustincich S, Santoro C, Sblattero D, Cotella D. (2015). Identification of novel proteins binding the AU-rich element of α-prothymosin mRNA through the selection of open reading frames (RIDome). RNA Biol 12(12):1289. IF: 4.076.

9.      Calligaris S, Banica M, Roncaglia P, Robotti E, Finaurini S, Vlachouli C, Antonutti L, Iorio F, Carissimo A, Cattaruzza T, Ceiner A, Lazarevic D, Cucca A, Pangher P, Marengo E, di Bernardo D, Pizzolato P, Gustincich S. (2015). Blood transcriptomics of drug-naive sporadic Parkinson’s disease patients. BMC Genomics 16:876. IF: 3.867.

10.  Patrucco L, Chiesa A, Soluri MF, Fasolo F, Takahashi H, Carninci P, Zucchelli S, Santoro C, Gustincich S, Sblattero D, Cotella D. (2015). Engineering mammalian cell factories with SINEUP noncoding RNAs to improve translation of secreted proteins. Gene 569(2):287-93. IF: 2.319.

11.  Zucchelli S, Fasolo F, Russo R, Cimatti L, Patrucco L, Takahashi H, Jones MH, Santoro C, Sblattero D, Cotella D, Persichetti F, Carninci P, Gustincich S. (2015). SINEUPs are modular antisense long-non coding RNAs that increase synthesis of target proteins in cells. Front Cell Neurosci 9:174. IF: 4.609.

12.  Carrieri C, Forrest A, Santoro C, Persichetti F, Carninci P, Zucchelli S#, Gustincich S#. (2015). Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells’ differentiation in vitro and in neurochemical models of Parkinson’s disease. #Corresponding authors. Front Cell Neurosci 9:114. IF: 4.609.

13.  Liang C; FANTOM Consortium, Forrest AR, Wagner GP. (2015). The statistical geometry of transcriptome divergence in cell-type evolution and cancer. Nat Commun. 6:6066. IF: 11.329.

14.  Grison A*, Zucchelli S,*, Urzì A, Zamparo I, Lazarevic D, Pascarella G, Roncaglia P, Giorgetti A, Garcia-Esparcia P, Vlachouli C, Simone R, Persichetti F, Forrest A, Hayashizaki Y, Carloni P, Ferrer I, Lodovichi C, Plessy C, The FANTOM Consortium, Carninci P#, Gustincich S#. (2014). Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules. *These authors equally contributed to the work. #Corresponding authors. BMC Genomics 15:729. IF: 3.986.

15.  Pascarella G, Lazarevic D, Plessy C, Bertin N, Akalin A, Vlachouli C, Simone R, Faulkner GJ, Zucchelli S, Kawai J, Daub CO, Hayashizaki Y, Lenhard B, Carninci P#, Gustincich S#. (2014). NanoCAGE analysis of the mouse olfactory epithelium identifies the expression of vomeronasal receptors and of proximal LINE elements. #Corresponding authors. Front Cell Neurosci 8:41. IF: 4.289.

16.  Aulić S, Le TT, Moda F, Abounit S, Corvaglia S, Casalis L, Gustincich S, Zurzolo C, Tagliavini F, Legname G. (2014). Defined a-synuclein prion-like molecular assemblies spreading in cell culture. BMC Neurosci 4;15(1):69. IF: 2.665.

17.  Aspesi A, Pavesi E, Robotti E, Crescitelli R, Boria I, Avondo F, Moniz H, Da Costa L, Mohandas N, Roncaglia P, Ramenghi U, Ronchi A, Gustincich S, Merlin S, Marengo E, Ellis SR, Follenzi A, Santoro C, Dianzani I. (2014). Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond Blackfan Anemia. Gene 545(2):282-9. IF: 2.138.

18.  FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Lassmann T, Itoh M, Summers KM, Suzuki H, Daub CO, Kawai J, Heutink P, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, Sandelin A, Hume DA, Carninci P, Hayashizaki Y. (2014). A promoter-level mammalian expression atlas. Nature 507(7493):462-70. IF: 41.456.

19.  Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F; FANTOM Consortium, Forrest AR, Carninci P, Rehli M, Sandelin A. (2014). An atlas of active enhancers across human cell types and tissues. Nature 507(7493):455-61. IF: 41.456.

20.  Fabbro A, Sucapane A, Toma FM, Calura E, Rizzetto L, Carrieri C, Roncaglia P, Martinelli V, Scaini D, Masten L, Turco A, Gustincich S, Prato M, Ballerini L. (2013). Adhesion to carbon nanotube conductive scaffolds forces action-potential appearance in immature rat spinal neurons. PLoS ONE 8(8):e73621. IF 3.730.

21.  Mancini C, Roncaglia P, Brussino A, Stevanin G, Lo Buono N, Krmac H, Maltecca F, Gazzano E, Bartoletti Stella A, Calvaruso MA, Iommarini L, Cagnoli C, Forlani S, Le Ber I, Durr A, Brice A, Ghigo D, Casari G, Porcelli AM, Funaro A, Gasparre G, Gustincich S, Brusco A. (2013). Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. BMC Med Genomics 6:22. IF 3.466.

22.  Russo R*, Zucchelli S*, Codrich M, Marcuzzi F, Verde C, Gustincich S. (2013). Hemoglobin is present as a canonical α2β2 tetramer in dopaminergic neurons. *These authors equally contributed to the work. BBA Proteins and Proteomics 1834(9):1939-43. IF: 3.733.

23.  Garcia-Esparcia P, Schlüter A, Carmona M, Moreno J, Ansoleaga B, Torrejón-Escribano B, Gustincich S, Pujol A, Ferrer I. (2013). Functional Genomics Reveals Dysregulation of Cortical Olfactory Receptors in Parkinson Disease: Novel Putative Chemoreceptors in the Human Brain. J Neuropathol Exp Neurol 72(6):524-39. IF: 4.345.

24.  Tang DT, Plessy C, Salimullah M, Suzuki AM, Calligaris R, Gustincich S, Carninci P. (2013). Suppression of artifacts and barcode bias in high-throughput transcriptome analyses utilizing template switching. Nucleic Acids Res 41(3):e44. IF: 8.278.

25.  Carrieri C*, Cimatti L*, Biagioli M, Beugnet A, Zucchelli S, Fedele S, Pesce E, Ferrer I, Collavin L, Santoro C, Forrest AR, Carninci P, Biffo S, Stupka E, Gustincich S. (2012). Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. *These authors equally contributed to the work. Nature 491(7424):454-7. IF: 38.597.

26.  Vilotti S, Codrich M, Dal Ferro M, Pinto M, Ferrer I, Collavin L, Gustincich S#,  Zucchelli S#. (2012). Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6. #Corresponding authors. PLoS ONE 7(4):e35051. IF: 3.730.

27.  Plessy C*, Pascarella G*, Bertin N*, Akalin A*, Carrieri C, Vassalli A, Lazarevic D, Severin J, Vlachouli C, Simone R, Faulkner GJ, Kawai J, Daub CO, Zucchelli S, Hayashizaki Y, Mombaerts P, Lenhard B#, Gustincich S#, Carninci P#. (2012). Promoter architecture of mouse olfactory receptor genes. *These authors equally contributed to the work. #Corresponding authors.Genome Res 22(3):486-97. IF: 14.397.

28.  Vilotti S, Biagioli M, Foti R, Dal Ferro M, Lavina ZS, Collavin L, Del Sal G, Zucchelli S#, Gustincich S#. (2012). The PML nuclear bodies-associated protein TTRAP regulates ribosome biogenesis in nucleolar cavities upon proteasome inhibition. #Corresponding authors. Cell Death Differ 19(3):488-500. IF: 8.371.

29.  Grison A*, Mantovani F*, Comel A, Agostoni E, Gustincich S, Persichetti F, Del Sal G. (2011). Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. *These authors equally contributed to the work. Proc Natl Acad Sci USA 108(44):17979-84. IF: 9.737.

30.  Baillie JK*, Barnett MW*, Upton KR*, Gerhardt DJ, Richmond TA, De Sapio F, Brennan PM, Rizzu P, Smith S, Fell M, Talbot RT, Gustincich S, Freeman TC, Mattick JS, Hume DA, Heutink P, Carninci P, Jeddeloh JA, Faulkner GJ. (2011). Somatic retrotransposition alters the genetic landscape of the human brain. *These authors equally contributed to the work. Nature 479(7374):534-7. IF: 38.597.

31.  Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, Trotti D. (2011). Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2. Glia 59(11):1719-1731. IF: 5.066.

32.  Losasso V, Pietropaolo A, Zannoni C, Gustincich S#, Carloni P#. (2011). Structural role of compensatory amino acid replacements in the α-synuclein protein. #Corresponding authors. Biochemistry 50(32):6994-7001. IF: 3.377.

33.  Caiazzo M, Dell'Anno MT, Dvoretskova E, Lazarevic D, Taverna S, Leo D, Sotnikova TD, Menegon A, Roncaglia P, Colciago G, Russo G, Carninci P, Pezzoli G, Gainetdinov RR, Gustincich S, Dityatev A, Broccoli V. (2011). Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476(7359):224-7. IF: 38.597.

34.  Taccioli C, Maselli V, Tegnér J, Gomez-Cabrero D, Altobelli G, Emmett W, Lescai F, Gustincich S, Stupka E. (2011). ParkDB: a Parkinson’s disease gene expression database. Database 18:bar007. IF: 4.200.

35.  Zucchelli S, Marcuzzi F, Codrich M, Agostoni E, Vilotti S, Biagioli M, Pinto M, Carnemolla A, Santoro C, Gustincich S, Persichetti F. (2011). Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation. J Biol Chem 286(28):25108-17. IF: 4.651.

36.  Benvegnù S*, Roncaglia P*, Agostini F, Casalone C, Corona C, Gustincich S, Legname L. (2011). Developmental influence of the cellular prion protein on the gene expression profile in mouse hippocampus. *These authors equally contributed to the work. Physiol Genomics 43(12):711-25. IF: 2.806.

37.  Ferrer I, Gómez A, Carmona M, Huesa G, Porta S, Riera-Codina M, Biagioli M, Gustincich S, Aso E. (2011). Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies. J Alzheimers Dis 23(3):537-50. IF: 4.174.

38.  Motti D, Le Duigou C, Eugène E, Chemaly N, Wittner L, Lazarevic D, Krmac H, Marstrand T, Valen E, Sanges R, Stupka E, Sandelin A, Cherubini E, Gustincich S#, Miles R#. (2010). Gene expression analysis of the emergence of epileptiform activity after focal injection of kainic acid into mouse hippocampus. #Corresponding authors. Eur J Neurosci 32(8):1364-79. IF: 3.753.

39.  Zucchelli S, Codrich M, Marcuzzi F, Pinto M, Vilotti S, Biagioli M, Ferrer I, Gustincich S. (2010). TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains. Hum Mol Genet 19(19):3759-70. IF: 7.692.

40.  Plessy C*#, Bertin N*#, Takahashi H*, Simone R*, Salimullah M, Lassmann T, Vitezic M, Severin J, Olivarius S, Lazarevic D, Hornig N, Orlando V, Bell I, Gao H, Dumais J, Kapranov P, Wang H, Davis CA, Gingeras TR, Kawai J, Daub CO, Hayashizaki Y, Gustincich S#, Carninci P#. (2010). Linking promoters to functional transcripts in small samples with nanoCAGE and CAGEscan. *These authors equally contributed to the work. #Corresponding authors. Nat Methods 7(7):528-34. IF: 23.565.

41.  Foti R, Zucchelli S, Biagioli M, Roncaglia P, Vilotti S, Calligaris R, Krmac H, Girardini JE, Del Sal G, Gustincich S. (2010). Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells. J Biol Chem 285(24):18565-74. IF: 4.651.

42.  Deganuto M, Cesaratto L, Bellarosa C, Calligaris R, Vilotti S, Renzone G, Foti R, Scaloni A, Gustincich S, Quadrifoglio F, Tiribelli C, Tell G. (2010). A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein. Proteomics 10(8):1645-57. IF: 4.132.

43.  Latawiec D, Herrera F, Bek A, Losasso V, Candotti M, Benetti F, Carlino E, Kranjc A, Lazzarino M, Gustincich S, Carloni P, Legname G. (2010). Modulation of alpha-synuclein aggregation by dopamine analogs. PLoS One 5(2):e9234. IF: 3.730.

44.  Foti C, Florean C, Pezzutto A, Roncaglia P, Tomasella A, Gustincich S, Brancolini C. (2009). Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system. Mol Cancer Ther 8(11):3140-50. IF: 5.599.

45.  Calligaris R, Bellarosa C, Foti R, Roncaglia P, Giraudi P, Krmac H, Tiribelli C, Gustincich S. (2009). A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells. BMC Genomics 10:543. IF: 4.397.

46.  Biagioli M *, Pinto M *, Cesselli D, Zaninello M, Lazarevic D, Roncaglia P, Simone R, Vlachouli C, Plessy C, Bertin N, Beltrami A, Kobayashi K, Gallo V, Santoro C, Ferrer I, Rivella S, Beltrami CA, Carninci P, Raviola E, Gustincich S. (2009). Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells. *These authors equally contributed to the work. Proc Natl Acad Sci USA 106(36):15454-9. IF: 9.737.

47.  Avondo F, Roncaglia P, Crescenzio N, Krmac H, Garelli E, Armiraglio M, Castagnoli C, Campagnoli MF, Ramenghi U, Gustincich S, Santoro C, Dianzani I. (2009). Fibroblasts from patients with Diamond-Blackfan anaemia show abnormal expression of genes involved in protein synthesis, amino acid metabolism and cancer. BMC Genomics 10:442. IF: 4.397.

48.  Valen E, Pascarella G, Chalk A, Maeda N, Kojima M, Kawazu C, Murata M, Nishiyori H, Lazarevic D, Motti D, Marstrand TT, Tang MH, Zhao X, Krogh A, Winther O, Arakawa T, Kawai J, Wells C, Daub C, Harbers M, Hayashizaki Y, Gustincich S, Sandelin A, Carninci P. (2009). Genome-wide detection and analysis of hippocampus core promoters using DeepCAGE. Genome Res 19(2):255-65. IF: 14.397.

49.  Zucchelli S, Vilotti S, Calligaris R, Lavina ZS, Biagioli M, Foti R, De Maso L, Pinto M, Gorza M, Speretta E, Casseler C, Tell G, Del Sal G, Gustincich S. (2009). Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations. Cell Death Differ 16(3):428-38. IF: 8.371.

50.  Herrera F*, Chesi A*, Paleologou KE, Schmid A, Munoz A, Vendruscolo M, Gustincich S#, Lashuel HA, Carloni P#. (2008). Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region. *These authors equally contributed to the work. #Corresponding authors. PLoS ONE 3(10):e3394. IF: 3.730.

51.  Fantini D, Vascotto C, Deganuto M, Bivi N, Gustincich S, Marcon G, Quadrifoglio F, Damante G, Bhakat KK, Mitra S, Tell G. (2008). APE1/Ref-1 regulates PTEN expression mediated by Egr-1. Free Radic Res 42(1):20-9. IF: 3.279.

52.  Merighi A, Bardoni R, Salio C, Lossi L, Ferrini F, Prandini M, Zonta M, Gustincich S, Carmignoto G. (2008). Presynaptic functional trkB receptors mediate the release of excitatory neurotransmitters from primary afferent terminals in lamina II (substantia gelatinosa) of postnatal rat spinal cord. Dev Neurobiol 68(4):457-75. IF: 4.423.

53.  Gibb SL, Boston-Howes W, Lavina ZS, Gustincich S, Brown RH Jr, Pasinelli P, Trotti D. (2007). A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. J Biol Chem 282(44):32480-90. IF: 4.651.

54.  Herrera F*, Zucchelli S*, Jezierska A*, Scotto Lavina Z, Gustincich S#, Carloni P#. (2007). On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson Disease A combined computational and in vitro study. *These authors equally contributed to the work. #Corresponding authors. J Biol Chem 282(34):24905-14. IF: 4.651.

55.  Dorenbos R, Contini M, Hirasawa H, Gustincich S, Raviola E. (2007). Expression of circadian clock genes in retinal dopaminergic cells. Vis Neurosci 24(4):573-80. IF: 1.475.

56.  Gustincich S, Sandelin A, Plessy C, Katayama S, Simone R, Lazarevic D, Hayashizaki Y,  Carninci P. (2006). The complexity of the mammalian transcriptome. J Physiol 575(Pt 2):321-32. IF: 4.380.

57.  Pifferi S*, Pascarella G*, Boccaccio A, Mazzatenta A, Gustincich S, Menini A, Zucchelli S. (2006). Bestrophin-2 is a candidate calcium-activated chloride channel involved in olfactory transduction. *These authors equally contributed to the work. Proc Natl Acad Sci USA 103(34):12929-34. IF: 9.737.

58.  Carninci P, Sandelin A, Lenhard B, Katayama S, Shimokawa K, Ponjavic J, Semple CA, Taylor MS, Engström PG, Frith MC, Forrest AR, Alkema WB, Tan SL, Plessy C, Kodzius R, Ravasi T, Kasukawa T, Fukuda S, Kanamori-Katayama M, Kitazume Y, Kawaji H, Kai C, Nakamura M, Konno H, Nakano K, Mottagui-Tabar S, Arner P, Chesi A, Gustincich S, Persichetti F, Suzuki H, Grimmond SM, Wells CA, Orlando V, Wahlestedt C, Liu ET, Harbers M, Kawai J, Bajic VB, Hume DA, Hayashizaki Y. (2006). Genome-wide analysis of mammalian promoter architecture and evolution. Nature Genetics 38(6):626-35. IF: 35.209.

59.  Tkatchenko AV, Walsh PA, Tkatchenko TV, Gustincich S, Raviola E. (2006). Form deprivation modulates retinal neurogenesis in primate experimental myopia. Proc Natl Acad Sci USA 103:4681-86. IF: 9.737.

60.  Cherubini E, Gustincich S, Robinson H. (2006). The mammalian transcriptome and the cellular complexity of the brain. J Physiol 575(Pt 2):319-20. IF: 4.380.

61.  FANTOM3 Consortium. (2005). The transcriptional landscape of the mammalian genome. Science 309(5740):1559-63. IF: 31.027.

62.  Mladinic M, Wintzer M, Del Bel E, Casseler C, Lazarevic D, Crovella S, Gustincich S, Cattaneo A, Nicholls J. (2005). Differential expression of genes at stages when regeneration can and cannot occur after injury to immature mammalian spinal cord. Cell Mol Neurobiol 25(2):407-26. IF: 2.293.

63.  Gustincich S, Contini M, Gariboldi M, Puopolo M, Kadota M, Bono H, LeMieux J, Walsh P, Carninci P, Hayashizaki Y, Okazaki Y, Raviola R. (2004). Gene discovery in genetically labeled single dopaminergic neurons of the retina. Proc Natl Acad Sci USA 101:5069-74. IF: 9.737.

64.  Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper M, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y. (2003). Targeting a complex transcriptome: The construction of the mouse full-length cDNA encyclopedia. Genome Research 13:1273-89. IF: 14.397.

65.  Gustincich S, Batalov S, Beisel KW, Bono H, Carninci P, Fletcher CF, Grimmond S, Hirokawa N, Jarvis ED, Jegla T, Kawasawa Y, LeMieux J, Miki H, Raviola E, Teasdale RD, Tominaga N, Yagi K, Zimmer A, Arakawa T, Waki K, Kawai J, Hayashizaki Y, Okazaki Y. (2003). Analysis of the mouse transcriptome for genes involved in the function of the nervous system. Genome Research 13:1395-401. IF: 14.397.

66.  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schonbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw (Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane(Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y. (2002). Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 420:563-73. IF: 38.597.

67.  Puopolo M, Hochstetler SE, Gustincich S, Wightman RM, Raviola E. (2001). Extrasynaptic release of dopamine from a retinal neuron: activity-dependence and neurotransmitter modulation. Neuron 30:211-25. IF: 15.766.

68.  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schonbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y. (2001). Functional annotation of a full-length mouse cDNA collection. Nature 409: 685-90. IF: 38.597.

69.  Feigenspan A, Gustincich S, Raviola E. (2000). Pharmacology of GABA(A) receptors of retinal dopaminergic neurons. J Neurophysiol 84:1697-707. IF: 3.301.

70.  Hochstetler S, Puopolo M, Gustincich S, Raviola E, Wightman RM. (2000). Real-time amperometric measurements of zeptomole quantities of dopamine released from neurons. Anal Chem 72:489-96. IF: 5.695.

71.  Gustincich S, Feigenspan A, Sieghart W, Raviola E. (1999). Composition of the GABAA receptors of retinal dopaminergic neurons. J Neurosci 19(18):7812-22. IF: 6.908.

72.  Gustincich S, Vatta P, Goruppi S, Wolf M, Saccone S, Della Valle G, Baggiolini M, Schneider C. (1999). The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. Genomics 57(1):120-9. IF: 3.010.

73.  Feigenspan A, Gustincich S, Bean B, Raviola E. (1998). Spontaneous activity of solitary dopaminergic cells of the retina. J Neurosci 18(17):6776-89. IF: 6.908.

74.  Gustincich S, Feigenspan A, Wu DK, Koopman LJ, Raviola E. (1997). Control of dopamine release in the retina: a transgenic approach to neural networks. Neuron 18:723-36. IF: 15.766.

75.  Goruppi S, Gustincich S, Brancolini C, Lee W, Schneider C. (1994). Dissection of c-myc domains involved in S Phase induction of NIH3T3 fibroblasts. Oncogene 9:1537-44. IF: 7.357.

76.  Del Sal G, Manfioletti G, Gustincich S, Ruaro E, Schneider C. (1994). New lambda and plasmid vectors for expression cloning in mammalian cells. BioTechniques 16:134-38. IF: 2.399.

77.  Gustincich S, Schneider C. (1993). Serum deprivation response gene is induced by serum starvation but not by contact inhibition. Cell Growth Differ 4:753-60. IF: 4.353.

78.  Fattorini P, Cacciò S, Gustincich S, Altamura BM, Graziosi G.(1993). Sex identification by PCR of a-satellite in aged tissue samples. Electrophoresis 14:23-6. IF: 3.261.

79.  Gustincich S, Carninci P, Schneider C. (1991). A rapid method to extract high-quality genomic DNA from Yeast. Technique 3:76-77.

80.  Rojas-Martinez A, Vazquez-Aleman RM, Gustincich S, Cantù JM, Barrera-Saldana HA. (1992). Genetica molecular de la fibrosis quistica: el alelo dF508 en familias mexicanas. Bol Med Hosp Infant Mex 49:335-41.

81.  Gustincich S, Manfioletti G, Del Sal G, Schneider C, Carninci P. (1991). A fast method for high-quality genomic DNA extraction from whole human blood. BioTechniques 11:298-302. IF: 2.399.

82.  Fattorini P, Cacciò S, Gustincich S, Wolfe J, Altamura BM, Graziosi G. (1991). Sex determination and species exclusion in forensic samples using probe cY97. Int J Legal Med 104:247-50. IF: 2.686.

83.  Carninci P, Gustincich S, Bottega S, Patrosso C, Del Sal G, Manfioletti G, Schneider C. (1990). A simple discontinuous buffer system for increased resolution and speed in gel electrophoretic analysis of DNA sequence. Nucleic Acids Res 18:204. IF: 8.278.

84.  Fattorini P, Cacciò S, Gustincich S, Altamura BM, Graziosi G. (1989). Sex determination from skeleton: a new method using a DNA probe. Acta Medicinae Legalis Et Socialis 39:201-5.

85.  Fattorini P, Cacciò S, Gustincich S, Altamura BM, Graziosi G. (1989). Sex determination in forensic samples using a DNA probe. Acta Medicinae Legalis Et Socialis 39:195-9.

 

86.  Fattorini P, Cacciò S, Gustincich S, Altamura BM, Graziosi G. (1989). Identificazione del sesso in reperti medico legali per mezzo di una sonda di DNA (CY97). Rivista Italiana di Medicina Legale 3:979-90.

Awards

Honors and Awards

 

2011                            1st prize (out of 2500 participants) with the PARKscreen project, Working Capital National Award (Italian national prize for Innovation in biotechnology).

2011                            1st prize with the PARKscreen project, Start Cup Regional Competition (Italian Region Friuli Venezia Giulia business plan competition).

2003                           The Giovanni Armenise-Harvard Foundation career development award.

2002                           Charles A. King Trust, The Medical Foundation fellowship award.

1994                           European Molecular Biology Organization (EMBO) long-term fellowship.

1992                                       Area Science Park award for young scientists involved in biotechnology research, Trieste, Italy.

 

1989                            Antonio Marzullo award for best BS thesis of the year in Biological Sciences, Trieste, Italy.

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.