Postdoctoral position in Structural biophysics - [ Postdoc ]

Workplace: Genova, IIT
Added on: 28/05/2019 - Expires on: 12/06/2019

A post-doctoral position in structural biophysics is available at Istituto Italiano di Tecnologia in Genova in the Computational and Chemical Biology Research Line led by Prof. Andrea Cavalli.

The position is for biologists with hands-on research experience in expression and purification of recombinant proteins from different host cells (bacteria, mammalian cells, yeast, insect cells, etc.) and significant experience with various protein purification methods. The position requires a marked interest in implementing a vast variety of complementary biophysical approaches and familiarity with at least some of the following biophysical techniques for protein structural characterization: Nuclear Magnetic Resonance Spectroscopy (NMR), cryo-electron microscopy (cryo-EM) and X-ray crystallography. Experience in cell biology, in particular in cancer cell biology will also be appreciated.

The successful candidate will play relevant roles in several drug discovery projects through the investigation of the structure-function relationships of proteins belonging to pathways relevant to specific human diseases. In particular, protein-protein and protein-DNA/RNA interactions will be investigated as crucial interplays in the pathological processes. The final goal is to understand disease mechanisms by providing insights into the function and dysfunction of proteins and design new therapeutic strategies through the identification and characterization of the activity of small molecule/peptide inhibitors of relevant pathological targets. Within these projects, the candidate must be able to work independently and collaboratively in a highly interdisciplinary environment in close contact with both computational and experimental researchers. The candidate will also tutor junior PhD and master students.

The candidate must possess a PhD in physical chemistry, biochemistry, biology, or related disciplines, being outstanding and highly-motivated scientists with strong records of research productivity.

Excellent English communication skills, creativity and marked enthusiasm for research are mandatory.

Salary and benefits will be in line with international standards.

The closing date for applications is June 11, 2019. Please send your application, including your CV and names of 2 referees, to quoting “Postdoctoral position Structural Biology CB 76762” in the subject line.

Istituto Italiano di Tecnologia is a private law Foundation, created with special Government Law no. 269 of September 30th 2003, with the objective of promoting Italy's technological development and higher education in science and technology. Research at IIT is carried out in highly innovative scientific fields with state-of-the-art technology.

We inform you that the information you provide will be used solely for the purposes of evaluating and selecting professional profiles in order to meet the requirements of Istituto Italiano di Tecnologia.

Your data will be processed by Istituto Italiano di Tecnologia, based in Genoa, Via Morego 30, acting as Data Controller, in compliance with the rules on protection of personal data, including those related to data security.

Please also note that, pursuant to articles 15 et. seq. of European Regulation no. 679/2016 (General Data Protection Regulation), you may exercise your rights at any time by contacting the Data Protection Officer (phone +39 010 71781 - email: dpo[at]

Istituto Italiano di Tecnologia is an Equal Opportunity Employer that actively seeks diversity in the workforce.

Involved Research lines
Computational and Chemical Biology


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