The Center for Genomic Science applies modern genomic technologies towards a better understanding of complex biological processes and diseases, with particular emphasis on Cancer.
The Center is located within the IFOM-IEO Campus in Milan, one of the largest and most vibrant cancer research communities in Europe. The Center provides state-of-the art technological platforms for functional as well as structural genomics, and benefits from all the infrastructure, technological platforms and didactic activities already present in the IFOM-IEO Campus. Our PhD program is integrated with that of SEMM, the European School of Molecular Medicine.
The mission of our Center is to identify changes in the genome that underlie the development of cancer, as well as its susceptibility to therapeutic intervention. Our general aim is to reduce pathological traits into their molecular components, which might correspond to disease markers or potential targets for pharmacological intervention. We will exploit these molecular markers and targets in order to build up strategic programs for disease prevention, early detection and treatment.
The Center hosts the Genomic Science research line. Science activities are divided in four main branches:
We study the function and regulation of non-coding transcripts (miRNAs and long non-coding RNAs), with a particular emphasis on how regulatory RNAs shape the identity and properties of mammalian cells in cancer stem cells and during cancer evolution (therapy resistance, metastatic spread)
We combine genetically modified mouse models (GEMMs) that faithfully recapitulate tumor progression with forward and reverse genetic screenings for the identification of transcriptional and epigenomic alterations causally involved in cancer.
We apply an interdisciplinary approach combining mathematical modeling and genomics to study the dynamics of transcription (including RNA synthesis, processing and degradation), and how these are affected by RNA modifications and chromatin regulation in cancer.
we develop computational methods and algorithms to study the function and regulation of RNA molecules, with a particular focus on the development of analytical strategies based on Nanopore direct RNA sequencing (dsRNAseq)