Francesca Macchi is a Post Doc in the Nanotechnology for Precision Medicine research line at Istituto Italiano di Tecnologia since October 2016. Her research activities focus on the development of polymeric micro constructs for local therapy of glioblastoma multiforme.
Dr Macchi achieved the PhD Degree in Biomedical Sciences at the Laboratory of Neurobiology and Gene Therapy, Dept. of Neuroscience, KU Leven, Belgium in April 2016. She presented a thesis titled “Characterization of synuclein aggregation, neuroinflammation and neurodegeneration in models of Parkinson’s disease” working on the development of cell-based assays for high content screening and validation of compounds against Parkinson’s disease and the characterization of neuroinflammatory response in cellular and in vivo models of Parkinson’s disease.
During her postgraduate training in Molecular and Cellular Biology, at the University of Pisa, she developed strong skills in cellular biology, stem cells, transgenic organisms, and developmental biology. She completed her Master Degree in 2008, presenting a thesis on the “Generation of a mouse model with a GCG triplet expansion in the ARX gene, identified in West Syndrome patients” supervised by Prof. Massimo Pasqualetti.
In 2009, between her PhD and Master, she worked as Research Fellow at the laboratory of Neurobiology CNR in Pisa on the following subjects:
- Analysis of gene expression profiles in mouse models of seizure susceptibility
- Characterization of murine models for autism spectrum disorders