The advancement of "biological twins", sophisticated in vitro models that replicate human brain functions, represents a significant leap in medical research and drug development. CERES project aims to revolutionize the study and treatment of brain pathologies, by integrating tissue-on-chip (TOC) and bioprinting technologies to create cerebral models. These models will provide advanced platforms for studying neurological disorders and developing targeted therapies. TOC models, created using microfluidic technology, cultivate living cells in perfusable chambers. Although smaller and simpler than their native counterparts, these models are complex enough to approximate distinct tissue phenotypes: molecular, structural and functional. On the other side, bioprinting technologies, utilizing both inkjet and extrusion methods, offer a powerful approach for fabricating sophisticated brain models for drug testing and research. Inkjet printing enables the precise deposition of cells and biomolecules, creating intricate tissue structures with defined cellular arrangements. Extrusion printing provides the necessary structural support for tissue growth. By integrating these technologies, CERES aims to develop models replicating the complex interplay between various cell types within the brain, offering a groundbreaking platform for studying neurological disorders and developing targeted therapies. This project holds immense potential for accelerating drug discovery and ultimately improving treatment strategies for neurological disorders by fostering a deeper understanding of disease mechanisms and drug interactions within these reliable models.