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Gianni Ciofani Write a Message

Senior Researcher
Associate Professor

Research Line

Smart Bio-Interfaces

Contacts

Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy

About

Gianni Ciofani (born on August 14th, 1982) is Associate Professor at the Polytechnic University of Torino, Department of Mechanical and Aerospace Engineering (Torino, Italy) and Senior Researcher at the Italian Institute of Technology (IIT), Smart Bio-Interfaces Research Line (Pontedera, Pisa, Italy).

He received his Master Degree in Biomedical Engineering (with honors) from the University of Pisa, Italy, in July 2006, and, in the same year, his Diploma in Engineering (with honors) from the Scuola Superiore Sant’Anna of Pisa, Italy. In January 2010, he obtained his Ph.D. in Innovative Technologies (with honors) from the Scuola Superiore Sant’Anna. From January 2010 to August 2013 he was Post-Doc at the IIT, Center for Micro-BioRobotics @SSSA, where, from September 2013 to October 2015, he was Researcher in the framework of the Smart Materials Platform. In October 2015 he was appointed Associate Professor at the Polytechnic University of Torino, maintaining his research activity in IIT where he is currently Principal Investigator of the Smart Bio-Interfaces Research Line.

His main research interests are in the field of smart nanomaterials for nanomedicine, bio/non-bio interactions, and biology in altered gravity conditions. He is coordinator or unit leader of many grants/projects, and in 2016 he was awarded a European Research Council (ERC) Starting Grant. Gianni Ciofani is author of about 90 ISI papers (H-index 21, excluding self-citations), 2 edited books, 12 book chapters and 2 applications of international patents. He delivered about 15 invited talks/lectures in international contexts and, for his research activity, he was awarded several national and international prizes. He serves as Reviewer for more than 100 international journals, and is an Editorial Board Member of the International Journal of Biological Engineering, of Advances in Nano Research, and Senior Editor of Nanomaterials & Nanosciences.

Gianni Ciofani is professor of Biomimetic Systems and Bionanotechnologies, and supervisor of several M.Sc. and Ph.D. students.

Projects

Granted projects

  1. Magnetic solid lipid nanoparticles as a multifunctional platform against glioblastoma multiforme (SLaMM), grant number 709613, European Research Council (ERC) Starting Grant, 2017-2022
  2. Nanotechnology solutions against oxidative stress in muscle tissue during long-term microgravity exposure (NANOROS), grant number 2016-7-U.0, Italian Space Agency, 2016-2018
  3. Starting grant "Compagnia di San Paolo", grant number 55_AI16GC01, Compagnia di San Paolo, 2016-2018
  4. New self-powered devices for cochlear stimulation based on piezoelectric nanomaterials, grant number RF-2011-02350464, Italian Ministry of Health, 2014-2017

Other projects

  1. Nanotechnological countermeasures against oxidative stress in muscle cells exposed to microgravity, project number ILSRA-2014-0012, European Space Agency, 2015-2018
  2. In vitro effects of the Bayer’s proprietary compound BAY 43-9006 (Sorafenib) linked to magnetic nanoparticles on HepG2 cell line, project number US208314731, Bayer HealthCare Pharmaceuticals Inc., 2014-2016

Selected Publications

International journals

  1. Genchi G.G., Marino A., Grillone A., Pezzini I., Ciofani G. Remote control of cellular functions: the role of smart nanomaterials in the medicine of the future. Advanced Healthcare Materials, 10.1002/adhm.201700002
  2. Marino A., Arai S., Hou Y., Degl'Innocenti A., Cappello V., Mazzolai B., Chang Y.T., Mattoli V., Suzuki M., Ciofani G. Gold nanoshell-mediated remote myotube activation. ACS Nano, 10.1021/acsnano.6b08202
  3. Marino A., Genchi G.G., Mattoli V., Ciofani G. Piezoelectric nanotransducers: the future of neural stimulation. Nano Today, 10.1016/j.nantod.2016.12.005
  4. Pezzini I., Mattoli V., Ciofani G. Mitochondria and neurodegenerative diseases: The promising role of nanotechnology in targeted drug delivery. Expert Opinion on Drug Delivery, 10.1080/17425247.2016.1218461
  5. Pezzini I., Marino A., Del Turco S., Nesti C., Doccini S., Cappello V., Gemmi M., Parlanti P., Santorelli F.M., Mattoli V., Ciofani G. Cerium oxide nanoparticles, the regenerative redox machine in bioenergetic imbalance. Nanomedicine UK, 12(4): 403-416 (2017)
  6. Calucci L., Grillone A., Redolfi Riva E., Mattoli V., Ciofani G., Forte C. NMR relaxometric properties of SPION-loaded solid lipid nanoparticles. Journal of Physical Chemistry C, 121(1): 823-829 (2017)
  7. Marino A., Tonda-Turo C., De Pasquale D., Ruini F., Genchi G.G., Nitti S., Cappello V., Gemmi M., Mattoli V., Ciardelli G., Ciofani G. Gelatin/nanoceria nanocomposite fibers as antioxidant scaffolds for neuronal regeneration. Biochimica et Biophysica Acta - General Subjects, 1861(2): 386-395 (2017)
  8. Genchi G.G., Rocca A., Marino A., Grillone A., Mattoli V., Ciofani G. Hypergravity as a tool for cell stimulation: Implications in biomedicine. Frontiers in Astronomy and Space Sciences, 3: 26 (2016)
  9. Genchi G.G., Ceseracciu L., Marino A., Labardi M., Marras S., Pignatelli F., Bruschini L., Mattoli V., Ciofani G. P(VDF-TrFE)/BaTiO3 nanoparticle composite films mediate piezoelectric stimulation and promote differentiation of SH-SY5Y neuroblastoma cells. Advanced Healthcare Materials, 5(14): 1808-1820 (2016)
  10. Mattu C., Silvestri A., Wang T.R., Boffito M., Ranzato E., Cassino C., Ciofani G., Ciardelli G. Surface-functionalized polyurethane nanoparticles for targeted cancer therapy. Polymer International, 65(7): 770-779 (2016)
  11. Piazza V., de Vito G., Farrokhtakin E., Ciofani G., Mattoli V. Femtosecond-laser-pulse characterization and optimization for CARS microscopy, PLoS ONE 11(5): e0156371 (2016)
  12. Genchi G.G., Marino A., Rocca A., Mattoli V., Ciofani G. Barium titanate nanoparticles: Promising multitasking vectors in nanomedicine. Nanotechnology, 27(23): 232001 (2016)
  13. Rocca A., Marino A., del Turco S., Cappello V., Parlanti P., Pellegrino M., Golberg D., Mattoli V., Ciofani G. Pectin-coated boron nitride nanotubes: In vitro cyto- / immune-compatibility on RAW 264.7 macrophages. Biochimica et Biophysica Acta - General Subjects, 1860(4): 775-784 (2016)
  14. Marino A., Barsotti J., de Vito G., Filippeschi C., Mazzolai B., Piazza V., Labardi M., Mattoli V., Ciofani G. Two-photon lithography of 3D nanocomposite piezoelectric scaffolds for cell stimulation. ACS Applied Materials and Interfaces, 7(46): 25574-25579 (2015)
  15. Genchi G.G., Ciofani G. Bioapplications of boron nitride nanotubes. Nanomedicine UK, 10(22): 3315-3319 (2015)
  16. Sergi P.N., Marino A., Ciofani G. Deterministic control of mean alignment and elongation of neuron-like cells by grating geometry: A computational approach. Integrative Biology, 7(10): 1242-1252 (2015)
  17. Mele E., Heredia-Guerrero J.A, Bayer I., Ciofani G., Genchi G.G., Ceseracciu L., Davis A., Papadopoulou E.L., Barthel M.J., Marini L., Ruffilli R., Athanassiou A. Zwitterionic nanofibers of super-glue for transparent and biocompatible multi-purpose coatings. Scientific Reports, 5: 14019 (2015)
  18. Rocca A., Moscato S., Ronca F., Nitti S., Mattoli V., Giorgi M., Ciofani G. Pilot in vivo investigation of cerium oxide nanoparticles as a novel anti-obesity pharmaceutical formulation. Nanomedicine: Nanotechnology, Biology and Medicine, 11(7): 1725-1734 (2015)
  19. Grillone A., Redolfi Riva E., Mondini A., Forte C., Calucci L., Innocenti C., de Julian Fernandez C., Cappello V., Gemmi M., Moscato S., Ronca F., Sacco R., Mattoli V., Ciofani G. Active targeting of sorafenib: Preparation, characterization, and in vitro testing of drug-loaded magnetic solid lipid nanoparticles. Advanced Healthcare Materials, 4(11): 1681-1690 (2015)
  20. Marino A., Arai S., Hou Y., Sinibaldi E., Pellegrino M., Chang Y.T., Mazzolai B., Mattoli V., Suzuki M., Ciofani G. Piezoelectric nanoparticle-assisted wireless neuronal stimulation. ACS Nano, 9(7): 7678-7689 (2015)
  21. Danti S., Ciofani G., Pertici G., Moscato S., D'Alessandro D., Ciabatti E., Chiellini F., D'Acunto M., Mattoli V., Berrettini S. Boron nitride nanotube-functionalized myoblast/microfiber constructs: a nanotech-assisted tissue-engineered platform for muscle stimulation. Journal of Tissue Engineering and Regenerative Medicine, 9(7): 847-851 (2015)
  22. Salvetti A., Rossi L., Iacopetti P., Li X., Nitti S., Pellegrino T., Mattoli V., Golberg D., Ciofani G. In vivo biocompatibility of boron nitride nanotubes: Effects on stem cell biology and tissue regeneration in planarians. Nanomedicine UK, 10(12): 1911-1922 (2015)
  23. Ferreira T.H., Rocca A., Marino A., Mattoli V., de Sousa E.M.B., Ciofani G. Evaluation of the effects of gum Arabic functionalized boron nitride nanotubes on the differentiation of rat mesenchymal stem cells. RSC Advances, 5(56): 45431-45438 (2015)
  24. Bernardeschi I., Greco F., Ciofani G., Marino A., Mattoli V., Mazzolai B., Beccai L. A soft, stretchable and conductive biointerface for mechanotransduction studies. Biomedical Microdevices, 17(2): 46 (2015)
  25. Genchi G.G., Cialdai F., Monici M., Mazzolai B., Mattoli V., Ciofani G. Hypergravity stimulation enhances PC12 neuron-like cell differentiation. BioMed Research International, 748121 (2015)
  26. Marino A., Filippeschi C., Mattoli V., Mazzolai B., Ciofani G. Biomimicry at the nanoscale: Current research and perspectives of two-photon polymerization. Nanoscale, 7(7): 2841–2850 (2015)
  27. Ferreira T.H., Marino A., Rocca A., Liakos I., Nitti S., Athanassiou A., Mattoli V., Mazzolai B., de Sousa E.M.B., Ciofani G. Folate-grafted boron nitride nanotubes: Possible exploitation in cancer therapy. International Journal of Pharmaceutics, 481(1-2): 56-63 (2015)
  28. Genchi G.G., Ciofani G., Polini A., Liakos I., Iandolo D., Athanassiou A., Pisignano D., Mattoli V., Menciassi A. PC12 neuron-like cell response to electrospun poly(3-hydroxybutyrate) substrates. Journal of Tissue Engineering and Regenerative Medicine, 9(2): 151-161 (2015)
  29. Rocca A., Marino A., Rocca V., Moscato S., de Vito G., Piazza V., Mazzolai B., Mattoli V., Ngo-Anh T.J., Ciofani G. Barium titanate nanoparticles and hypergravity stimulation improve differentiation of mesenchymal stem cells into osteoblasts. International Journal of Nanomedicine, 10: 433-445 (2015)
  30. Marino A., Desii A., Pellegrino M., Pellegrini M., Filippeschi C., Mazzolai B., Mattoli V., Ciofani G. Nano-structured Brownian surfaces prepared through two-photon polymerization: Investigation of stem cell response. ACS Nano, 8(11): 11869-11882 (2014)
  31. Rocca A., Mattoli V., Mazzolai B., Ciofani G. Cerium oxide nanoparticles inhibit adipogenesis in rat mesenchymal stem cells: Potential therapeutic implications. Pharmaceutical Research, 31(11): 2952-2962 (2014)
  32. Ciofani G., Genchi G.G., Mattoli V., Mazzolai B., Bandiera A. The potential of recombinant human elastin-like polypeptides for drug delivery. Expert Opinion on Drug Delivery, 11(10): 1507-1512 (2014)
  33. Marino A., Filippeschi C., Genchi G.G., Mattoli V., Mazzolai B., Ciofani G. The Osteoprint: A two-photon polymerized 3D structure for the enhancement of bone-like cell differentiation. Acta Biomaterialia, 10(10): 4303-4313 (2014)
  34. Ciofani G., Del Turco S., Rocca A., De Vito G., Cappello V., Yamaguchi M., Li X., Basta G., Mazzolai B., Gemmi M., Piazza V., Golberg D., Mattoli V. Cytocompatibility evaluation of gum Arabic coated ultra-pure boron nitride nanotubes on human cells. Nanomedicine UK, 9(6): 773-788 (2014)
  35. Redolfi Riva E., Desii A., Sinibaldi E., Ciofani G., Piazza V., Mazzolai B., Mattoli V. Polysaccharides/gold nanoshell composite as a nanopatch for laser-assisted tissue thermal ablation. ACS Nano, 8(6): 5552-5563 (2014)
  36. Ciofani G., Genchi G.G., Guardia P., Mazzolai B., Mattoli V., Bandiera A. Recombinant human elastin-like magnetic microparticles for drug delivery and targeting. Macromolecular Bioscience, 14(5): 632-642 (2014)
  37. Calucci L., Ciofani G., Mattoli V., Mazzolai B., Boni A., Forte C. NMR relaxation enhancement of water protons by Gd-doped boron nitride nanotubes. Journal of Physical Chemistry C, 118(12): 6473-6479 (2014)
  38. Ricotti L., das Neves R.P., Ciofani G., Canale C., Nitti S., Manna L., Mattoli V., Mazzolai B., Ferreira L., Menciassi A. Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts. Journal of Nanoparticle Research, 16(2): 2247 (2014)
  39. Ciofani G., Genchi G.G., Mazzolai B., Mattoli V. Transcriptional profile of genes involved in oxidative stress and antioxidant defense in PC12 cells following treatment with cerium oxide nanoparticles. Biochimica et Biophysica Acta - General Subjects, 1840(1): 495-506 (2014)
  40. Marino A., Ciofani G., Filippeschi C., Pellegrino M., Pellegrini M., Pasqualetti M., Mattoli V., Mazzolai B. Two-photon polymerization of sub-micrometric patterned surfaces: Investigation of cell-substrate interactions and improved differentiation of neuron-like cells. ACS Applied Materials and Interfaces, 5(24): 13012-13021 (2013)
  41. Danti S., Ciofani G., Moscato S., D'Alessandro D., Ciabatti E., Nesti C., Brescia R., Bertoni G., Pietrabissa A., Lisanti M., Petrini M., Mattoli V., Berrettini S. Boron nitride nanotubes and primary human osteoblasts: in vitro compatibility and biological interactions under low frequency ultrasound stimulation. Nanotechnology, 24(46): 465102 (2013)
  42. Del Turco S., Ciofani G., Cappello V., Gemmi M., Cervelli T., Saponaro C., Nitti S., Mazzolai B., Basta G., Mattoli V. Cytocompatibility evaluation of glycol-chitosan coated boron nitride nanotubes in human endothelial cells. Colloids and Surfaces B: Biointerfaces, 111: 142-149 (2013)
  43. Ricotti L., Fujie T., Vazão H., Ciofani G., Marotta R., Brescia R., Filippeschi C., Corradini I., Matteoli M., Mattoli V., Ferreira L., Menciassi A. Boron nitride nanotube-mediated stimulation of cell co-culture on micro-engineered hydrogels. PLoS One, 8(8): e71707 (2013)
  44. Ciofani G., Boni A., Calucci L., Forte C., Gozzi A., Mazzolai B., Mattoli V. Gd-doped BNNTs as T2-weighted MRI contrast agents. Nanotechnology, 24(31): 315101 (2013)
  45. Ciofani G., Genchi G.G., Liakos I., Cappello V., Gemmi M., Athanassiou A., Mazzolai B., Mattoli V. Effects of cerium oxide nanoparticles on PC12 neuronal-like cells: Proliferation, differentiation and dopamine secretion. Pharmaceutical Research, 30(8): 2133-2145 (2013)
  46. Farrokhtakin E., Ciofani G., Puleo G.L., De Vito G., Filippeschi C., Mazzolai B., Piazza V., Mattoli V. Barium titanate core – gold shell nanoparticles for hyperthermia treatments. International Journal of Nanomedicine, 8: 2319-2331 (2013)
  47. Ciofani G., Danti S., Genchi G.G., Mazzolai B., Mattoli V. Boron nitride nanotubes: biocompatibility and potential spill-over in nanomedicine. Small, 9(9-10): 1672-1685 (2013)
  48. Ciofani G., Danti S., Nitti S., Mazzolai B., Mattoli V., Giorgi M. Biocompatibility of boron nitride nanotubes: an up-date of in vivo toxicological investigation. International Journal of Pharmaceutics, 444(1-2): 85-88 (2013)
  49. Genchi G.G., Ciofani G., Liakos I., Ricotti L., Ceseracciu L., Athanassiou A., Mazzolai B., Menciassi A., Mattoli V. Bio / non-bio interfaces: a straightforward method for obtaining long term PDMS / muscle cell biohybrid constructs. Colloids and Surfaces B: Biointerfaces, 105: 144-151 (2013)
  50. Ciofani G., Genchi G.G., Liakos I., Athanassiou A., Mattoli V., Bandiera A. Human recombinant elastin-like protein coatings for muscle cell proliferation and differentiation. Acta Biomaterialia, 9(2): 5111-5121 (2013)
  51. Ciofani G., Ricotti L., Canale C., D’Alessandro D., Berrettini S., Mazzolai B., Mattoli V. Effects of barium titanate nanoparticles on proliferation and differentiation of rat mesenchymal stem cells. Colloids and Surfaces B: Biointerfaces, 102: 312-320 (2013)
  52. Farrokhtakin E., Ciofani G., Gemmi G., Piazza V., Mazzolai B., Mattoli V. Synthesis and characterization of new barium titanate core - gold shell nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 415: 247-254 (2012)
  53. Ciofani G., Del Turco S., Genchi G.G., D’Alessandro D., Basta G., Mattoli V. Transferrin-conjugated boron nitride nanotubes: protein grafting, characterization, and interaction with human endothelial cells. International Journal of Pharmaceutics, 436(1-2): 444-453 (2012)
  54. Ricotti L., Polini A., Genchi G.G., Ciofani G., Iandolo D., Vazao H., Mattoli V., Ferreira L., Menciassi A., Pisignano D. Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds. Biomedical Materials, 7(3): 035010 (2012)
  55. Ciofani G., Genchi G.G., Liakos I., Athanassiou A., Dinucci D., Chiellini F., Mattoli V. A simple approach to covalent functionalization of boron nitride nanotubes. Journal of Colloid and Interface Science, 374(1): 308-314 (2012)
  56. Ciofani G., Ricotti L., Rigosa J., Menciassi A., Mattoli V., Monici M. Hypergravity effects on myoblast proliferation and differentiation. Journal of Bioscience and Bioengineering, 113(2): 258-261 (2012)
  57. Ciofani G., Danti S., Genchi G.G., D’Alessandro D., Pellequer J.L., Odorico M., Mattoli V., Giorgi G. Pilot in vivo toxicological investigation of boron nitride nanotubes. International Journal of Nanomedicine, 7: 19-24 (2012)
  58. Ciofani G., Genchi G.G., Mattoli V. ZnO nanowire arrays as substrates for cell proliferation and differentiation. Materials Science and Engineering: C, 32(2): 341-347 (2012)
  59. Menichetti L., De Marchi D., Calucci L., Ciofani G., Menciassi A., Forte C. Boron nitride nanotubes for boron neutron capture therapy as contrast agents in magnetic resonance imaging at 3 T. Applied Radiation and Isotopes, 69(12): 1725-1727 (2011)
  60. Pensabene V., Taccola S., Ricotti L., Ciofani G., Menciassi A., Perut F., Salerno M., Dario P., Baldini N. Flexible polymeric ultrathin film for mesenchymal stem cell differentiation. Acta Biomaterialia, 7(7): 2883-2891 (2011)
  61. Ciofani G., Ricotti L., Menciassi A., Mattoli V. Preparation, characterization and in vitro testing of poly(lactic-co-glycolic) acid / barium titanate nanoparticle composites for enhanced cellular proliferation. Biomedical Microdevices, 13(2): 255-266 (2011)
  62. Ciofani G., Danti S., Ricotti L., D’Alessandro D., Moscato S., Berrettini S., Mattoli V., Menciassi A. Boron nitride nanotubes: production, properties, biological interactions and potential applications as therapeutic agents in brain diseases. Current Nanoscience, 7(1): 94-109 (2011)
  63. Ciofani G., Sergi P.N., Carpaneto J., Micera S. A hybrid approach for the control of axonal outgrowth: preliminary simulation results. Medical and Biological Engineering and Computing, 49(2): 163-170 (2011)
  64. Ciofani G., Danti S., D’Alessandro D., Ricotti L., Moscato S., Bertoni G., Falqui A., Berrettini S., Petrini M., Mattoli V., Menciassi A. Enhancement of neurite outgrowth in neuronal-like cells following boron nitride nanotube-mediated stimulation. ACS Nano, 4(10): 6267-6277 (2010)
  65. Calucci L., Ciofani G., De Marchi D., Forte C., Menciassi A., Menichetti L., Positano V. Boron nitride nanotubes as T2-weighted MRI contrast agents. Journal of Physical Chemistry Letters, 1(17): 2561-2565 (2010)
  66. Ciofani G. Potential applications of boron nitride nanotubes as drug delivery systems. Expert Opinion on Drug Delivery, 7(8): 889-893 (2010)
  67. Ciofani G., Danti S., D’Alessandro D., Moscato S., Petrini M., Menciassi A. Barium titanate nanoparticles: highly cytocompatible dispersions in glycol-chitosan and doxorubicin complexes for cancer therapy. Nanoscale Research Letters, 5(7): 1093-1101 (2010)
  68. Raffa V., Ciofani G., Vittorio O., Pensabene V., Cuschieri A. Carbon nanotube-enhanced cell electropermeabilisation. Bioelectrochemistry, 79(1): 136-141 (2010)
  69. Ciofani G., Migliore A., Mazzei D., Carrozza M.C., Dario P. Modification of pointing performance in altered gravitational environments. Microgravity Science and Technology, 22(2): 123-128 (2010)
  70. Ciofani G., Ricotti L., Danti S., Moscato S., Nesti C., D’Alessandro D., Dinucci D., Chiellini F., Pietrabissa A., Petrini M., Menciassi A. Investigation of interactions between poly-L-lysine coated boron nitride nanotubes and C2C12 cells: up-take, cytocompatibility and differentiation. International Journal of Nanomedicine, 5: 285-298 (2010)
  71. Ciofani G., Danti S., D’Alessandro D., Moscato S., Menciassi A. Assessing cytotoxicity of boron nitride nanotubes: interference with the MTT assay. Biochemical and Biophysical Research Communications, 394(2): 405-411 (2010)
  72. Ciofani G., Danti S., Moscato S., Albertazzi L., D’Alessandro D., Dinucci D., Chiellini F., Petrini M., Menciassi A. Preparation of stable dispersion of barium titanate nanoparticles: potential applications in biomedicine. Colloids and Surfaces B: Biointerfaces, 76(2): 535-543 (2010)
  73. Raffa V., Ciofani G., Vittorio O., Riggio C., Cuschieri A. Physicochemical properties affecting cellular uptake of carbon nanotubes. Nanomedicine UK, 5(1): 89-97 (2010)
  74. Obata Y., Ciofani G., Raffa V., Cuschieri A. Menciassi A., Dario P., Takeoka S. Evaluation of cationic liposomes composed of an amino-acid-based lipid for neuronal transfection. Nanomedicine: Nanotechnology, Biology and Medicine, 6(1): 70-77 (2010)
  75. Raffa V., Vittorio O., Ciofani G., Pensabene V., Cuschieri A. Cell creeping and controlled migration by magnetic carbon nanotubes. Nanoscale Research Letters 5(1): 257-262 (2010)
  76. Ciofani G., Raffa V. Chemically functionalized carbon nanotubes: emerging vectors for cell therapy. Mini-reviews in Medicinal Chemistry, 9(11): 1251-1261 (2009)
  77. Riggio C., Ciofani G., Raffa V., Cuschieri A., Micera S. Combination of polymer technology and carbon nanotube array for the development of an effective drug delivery system at cellular level. Nanoscale Research Letter, 4(7): 668-673 (2009)
  78. Ciofani G., Riggio C., Raffa V., Menciassi A., Cuschieri A. A bi-modal approach against cancer: magnetic alginate nanoparticles for combined chemotherapy and hyperthermia. Medical Hypotheses, 73(1): 80-82 (2009)
  79. Ciofani G., Raffa V., Menciassi A., Cuschieri A., Micera S. Magnetic alginate microspheres: system for the position controlled delivery of nerve growth factor. Biomedical Microdevices, 11(2): 517-527 (2009)
  80. Bardi G., Tognini P., Ciofani G., Raffa V., Costa M., Pizzorusso T. Pluronic-coated carbon nanotubes do not induce degeneration of cortical neurons in vivo and in vitro. Nanomedicine: Nanotechnology, Biology and Medicine, 5(1): 96-104 (2009)
  81. Ciofani G., Obata Y., Sato I., Okamura Y., Raffa V., Menciassi A., Dario P., Takeda N., Takeoka S. Realization, characterization and functionalization of lipidic wrapped carbon nanotubes. Journal of Nanoparticle Research, 11(2): 477-484 (2009)
  82. Ciofani G., Raffa V., Yu J., Chen Y., Obata Y., Takeoka S., Menciassi A., Cuschieri A. Boron nitride nanotubes: a novel vector for targeted magnetic drug delivery. Current Nanoscience, 5(1): 33-38 (2009)
  83. Raffa V., Ciofani G., Cuschieri A. Enhanced low voltage cell electropermeabilization by boron nitride nanotubes. Nanotechnology, 20(7): 075104 (2009)
  84. Ciofani G., Raffa V., Menciassi A., Cuschieri A. Folate functionalised boron nitride nanotubes and their selective uptake by glioblastoma multiforme cells: implications for their use as boron carriers in clinical boron neutron capture therapy. Nanoscale Research Letters, 4(2): 113-121 (2009)
  85. Ciofani G., Raffa V., Menciassi A., Cuschieri A. Boron nitride nanotubes: an innovative tool for nanomedicine. Nano Today, 4(1): 8-10 (2009)
  86. Ciofani G., Raffa V., Pensabene V., Menciassi A., Dario P. Dispersion of multiwall carbon nanotubes in aqueous Pluronic F127 solutions for biological applications. Fullerenes Nanotubes and Carbon Nanostructures, 17(1): 11-25 (2009)
  87. Ciofani G., Raffa V., Menciassi A., Dario P. Preparation of boron nitride nanotubes aqueous dispersions for biological applications. Journal of Nanoscience and Nanotechnology, 8(12): 6223-6231 (2008)
  88. Ciofani G., Raffa V., Menciassi A., Cuschieri A. Cytocompatibility, interactions and uptake of polyethyleneimine-coated boron nitride nanotubes by living cells: confirmation of their potential for biomedical applications. Biotechnology and Bioengineering, 101(4): 850-858 (2008)
  89. Raffa V., Ciofani G., Nitodas S., Karachalios T., D’Alessandro D., Masini M., Cuschieri A. Can the properties of carbon nanotubes influence their internalization by living cells? Carbon, 46(12): 1600-1610 (2008)
  90. Ciofani G., Cascone M.G., Serino L.P., Lazzeri L. Urease loaded alginate microspheres for blood purification. Journal of Microencapsulation, 25(8): 569-576 (2008)
  91. Ciofani G., Raffa V., Pizzorusso T., Menciassi A., Dario P. Characterization of an alginate based drug delivery system for neurological applications. Medical Engineering and Physics, 30(7): 848-855 (2008)
  92. Ciofani G., Migliore A., Raffa V., Menciassi A., Dario P. Bi-compartmental device for dynamic cell co-culture: design, realisation and preliminary results. Journal of Bioscience and Bioengineering, 105(5): 536-544 (2008)
  93. Ciofani G., Raffa V., Menciassi A., Dario P. Alginate and chitosan particles as drug delivery system for cell therapy. Biomedical Microdevices, 10(2): 131-140 (2008)
  94. Ciofani G., Raffa V., Obata Y., Menciassi A., Dario P., Takeoka S. Magnetic driven alginate nanoparticles for targeted drug delivery. Current Nanoscience, 4(2): 212-218 (2008)
  95. Ciofani G., Raffa V., Menciassi A., Micera S., Dario P. A drug delivery system based on alginate microspheres: mass-transport test and in vitro validation. Biomedical Microdevices, 9(3): 395-403 (2007)

Edited books

  1. Ciofani G., Mattoli V. (Editors) Boron Nitride Nanotubes in Nanomedicine (Elsevier, UK, 2016)
  2. Ciofani G., Menciassi A. (Editors) Piezoelectric Nanomaterials for Biomedical Applications (Springer, Germany, 2012)

Book chapters

  1. Genchi G.G., Rocca A., Grillone A., Marino A., Ciofani G. Boron nitride nanotubes in nanomedicine: Historical and future perspectives. In "Boron Nitride Nanotubes in Nanomedicine", pp. 201-218, edited by Ciofani G., Mattoli V. (Elsevier, UK, 2016)
  2. Ciofani G., Mazzolai B., Mattoli V. Recent advancements in boron nitride nanotube biomedical research. In "Nanotubes and Nanosheets: Functionalization and Applications", pp. 575-585, edited by Chen Y. (CRC Press | Taylor & Francis Group, USA, 2015)
  3. Ciofani G. Piezoelectric quasi-1D nanostructures for biomedical applications. In "Contributi del Centro Linceo Interdisciplinare Beniamino Segre", Annuario delle Attività 2012, vol. 131, pp. 241-252 (Accademia Nazionale dei Lincei, Italy, 2014)
  4. Ciofani G. Piezoelectricity in nanomedicine: Future directions and perspectives. In “Piezoelectric Nanomaterials for Biomedical Applications”, pp. 239-245, edited by Ciofani G., Menciassi A. (Springer, Germany, 2012)
  5. Ciofani G., Danti S., Ricotti L., D’Alessandro D., Moscato M., Mattoli V. Applications of piezoelectricity in nanomedicine. In “Piezoelectric Nanomaterials for Biomedical Applications”, pp. 213-238, edited by Ciofani G., Menciassi A. (Springer, Germany, 2012)
  6. Ciofani G., Danti S. Evaluation of cytocompatibility and cell response to boron nitride nanotubes. In “Nanotechnology in Regenerative Medicine”, Methods in Molecular Biology Series, vol. 811, pp. 193-206, edited by Navarro M., Planell J.A. (The Humana Press, Springer, USA, 2012)
  7. Ricotti L., Ciofani G., Mattoli V., Menciassi A. Nano-doped matrices for tissue regeneration. In “Advances in Regenerative Medicine”, pp. 296-318, edited by Wislet-Gendebien S. (In-Tech, Croatia, 2011)
  8. Ciofani G. Nanotubes and their application to nanomedicine. In "Nanomedicine in Health and Disease", pp. 43-63, edited by Hunter R.J., Preedy V.R. (Science Publishers, CRC Press, USA, 2011)
  9. Raffa V., Vittorio O., Riggio C., Ciofani G., Cuschieri A. Physical properties of carbon nanotubes for therapeutic applications. In “Carbon Nanotubes for Biomedical Applications”, Carbon Nanostructures, part 1, pp. 3-26, edited by Klingeler R., Sim R.B. (Springer, Germany, 2011)
  10. Riggio C., Ciofani G., Raffa V., Bossi S., Micera S., Cuschieri A. Polymeric thin film technology for neural interfaces: Review and perspectives. In “Polymer Thin Films”, pp. 289-308, edited by Hashim A.A. (In-Tech, Croatia, 2010)
  11. Ciofani G., Raffa V., Vittorio O., Cuschieri A., Pizzorusso T., Costa M., Bardi G. In vitro and in vivo biocompatibility testing of functionalized carbon nanotubes. In “Carbon Nanotubes: Methods and Protocols”, Methods in Molecular Biology Series, vol. 625, pp. 67-84, edited by Burghard M., Balasubramanian K. (The Humana Press, Springer, USA, 2010)
  12. Ciofani G., Raffa V., Micera S. Innovative strategies for controlled delivery and release of NGF in neurological applications. In “Nerve Growth Factor: New Research”, pp. 91-140, edited by MacIntire G.K. (Nova Science Publishers, USA, 2008)

Patents

  1. Ciofani G., Raffa V., Danti S., Menciassi A., Dario P., Petrini M., Cuschieri A. Cellular electric stimulation mediated by piezoelectric nanotubes. Italian patent 0001394977, 07/08/2012
  2. Ciofani G., Migliore A., Raffa V., Menciassi A., Dario P. Multicompartmental and flow-variable bioreactor for comparative studies on cellular co-cultures. Italian patent 0001385850, 31/01/2011
  3. Raffa V., Menciassi A., Pensabene V., Ciofani G., Dario P. Non invasive method of electroporation mediated by carbon nanotubes and device for putting the method into practice. Italian patent 0001369160, 11/01/2010; US patent 8058043B2, 15/11/2011

Awards

  • Winner of the Spin Your Thesis! Campaign (2016), promoted by the ESA, presenting the experiment Hypergravity-induced oxidative stress in planarians: Nanotechnology-based countermeasures
  • Cover image of issue 4(11), August 2015, of Advanced Healthcare Materials
  • Cover image of issue 7(7), February 2015, of Nanoscale
  • Cover image of issue 31(11), November 2014, of Pharmaceutical Research
  • Winner of the Spin Your Thesis! Campaign (2014), promoted by the ESA, presenting the experiment Implementation of hypergravity in mammalian cell transfection procedures
  • Cover image of issue 14(5), May 2014, of Macromolecular Bioscience
  • Winner of the Spin Your Thesis! Campaign (2013), promoted by the ESA, presenting the experiment Combination of hypergravity and nanotechnology for the improvement of the differentiation of mesenchymal stem cells into osteoblasts
  • Cover image of issue 114(1), July 2012, of the Journal of Bioscience and Bioengineering
  • European Biomaterials and Tissue Engineering Doctoral Award (EDA 2011) for the Ph.D. Thesis
  • “Nital I-Robot - Scuola Superiore Sant’Anna” 2010 award for the Ph.D. Thesis
  • “Massimo Grattarola” 2010 award for the Ph.D. Thesis
  • Winner of the “Salvatore Venuta” 2010 scholarship for young researchers in nanomedicine
  • Winner of the Spin Your Thesis! Campaign (2010), promoted by the ESA, presenting the experiment Investigation of hypergravity on proliferation, metabolism and differentiation of muscle cells
  • STSBC-Roche 2009 award (Italian-Switzerland Society of Biomedical and Chemical Sciences and Roche Diagnostics Ltd.) for researches in the fields of biomedicine and/or biotechnology
  • Excellent Paper Award 2009 of the Society for Biotechnology of Japan, with the paper Bi-compartmental device for dynamic cell co-culture: design, realisation and preliminary results (Journal of Bioscience and Bioengineering, 105(5): 536-544, 2008)
  • AICC 2008 award (Italian Cell Culture Association, national branch of the European Tissue Culture Society) for young researchers in the biomedical field
  • ISIB-CNR 2006 award (Institute of Biomedical Engineering, National Research Council) for the Master Degree Thesis
  • Winner of the 8th Parabolic Flight Campaign (2005), promoted by the ESA and NOVESPACE, presenting the experiment Verification of the Fitts’ law in microgravity and hypergravity environment and energetic considerations
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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

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IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.

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