IIT People Search

Davide De Pietri Tonelli

Senior Researcher Tenured - Principal Investigator
Neurobiology of miRNA
Davide De Pietri Tonelli
Phone
+39 010 2896 725
Research center
CCT@Morego
Biografia

We aim at dissecting the molecular control of Neural Stem Cell (NSC) fate in mammalian neurogenesis by focusing on noncoding RNAs as key to understand and maintain brain plasticity and prevent tumours. 

Current Research in my group focuses on:i) Small RNAs in basic and translational aspects of neurogenesis in mammals. ii) Approaches enabling the use of small RNAs as diagnostic/prognostic tools for neuropathologies and therapeutic molecules against brain cancers.

Experience External

Title: Contract Professor of “Developmental Neurobiology” for the Master degree in biotechnology
Institute: Università di Genova
Location: Genoa
Country: italy
From: 2018 To: null

Title: Contract Professor of “Neural stem cell differentiation” for the Master degree in Molecular and Cell Biology
Institute: Università di Genova
Location: Genoa
Country: italy
From: 2008 To: 2010

Title: External collaborator
Institute: Clontech inc. (Mountain View, CA, USA).
Location: Mountain View (CA)
Country: USA
From: 2006 To: 2006

Title: Researcher
Institute: Max-Planck Institute of Molecular Cell-Biology and Genetics
Location: Dresden
Country: Germany
From: 2004 To: 2008

Title: Fellow
Institute: DIBIT-San Raffaele Reserch Institute
Location: Milan
Country: Italy
From: 1999 To: 2003

Top Publications
2025
Beatini S., La Rosa L., De Pietri Tonelli D.
PIWI-interacting RNAs in neurological and neuropsychiatric disorders and potential for clinical development
Brain Organoid and Systems Neuroscience Journal
DOI 10.1016/j.bosn.2025.06.003
Article Journal
2025
Rancati S., Pereira R.C., Schlich M., Sgroi S., Beatini S., La Rosa L., Giantomasi L., Pelizzoli R., Braccia C., Di Fonzo A., Spattini C., Tuntevski K., Lo Van A., Pons-Espinal M., Palange A., Bajetto A., Daga A., Armirotti A., Florio T., Decuzzi P., De Pietri Tonelli D.
Synergic microRNAs suppress human glioblastoma progression by modulating clinically relevant targets
Molecular Therapy - Nucleic Acids, vol. 36, (no. 4)
DOI 10.1016/j.omtn.2025.102763
2024
Tuntevski K., Giantomasi L., Paolini A., Baldassarre A., Pelizzoli R., Decherchi S., Perilli S., Di Fino L., Negri B., Miller J., Narici L., De Vivo M., Masotti A., Pezzilli S., De Pietri Tonelli D.
AstRNAuts: Monitoring space-induced stress by small rnas in body fluids.
75th International Astronautical Conference, pp. 617-626
DOI 10.52202/078355-0081
Conference Paper Conference
2023
Gasperini C., Tuntevski K., Beatini S., Pelizzoli R., Lo Van A., Mangoni D., Cossu R.M., Pascarella G., Bianchini P., Bielefeld P., Scarpato M., Pons-Espinal M., Sanges R., Diaspro A., Fitzsimons C.P., Carninci P., Gustincich S., De Pietri Tonelli D.
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus
EMBO Reports, vol. 24, (no. 2)
DOI 10.15252/embr.202153801
2017
Barca-Mayo O., Pons-Espinal M., Follert P., Armirotti A., Berdondini L., De Pietri Tonelli D.
Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
Nature Communications, vol. 8
DOI 10.1038/ncomms14336
All Publications
2026
Burton C., Beatini S., Perna A., Ribeiro J., Stubbendorff C., Orban G., Vincenzi M., Salemi E., Angotzi G. N., Fachechi L., Mastronardi V., Zapata S. C., Gomes G. M., Caltabiano A., Nava L., Giantomasi L., Latella C., De Pietri Tonelli D., De Vittorio M., Pucci D., Tonini R., Berdondini L.
BRAINBOX: Biomechanical Research and AI-Integrated Neuroscience BOX
MNESYS - final event
Poster Conference
2025
Spattini S., La Rosa L., Pereira R.C., Giantomasi L., Pelizzoli R., Tuntevski K., Battaglia G., Di Fonzo A., Armirotti A., De Pietri Tonelli D.
A microRNA-based Therapy against Human Medulloblastoma Validated in a Xenotransplant Model using Wild-Type Mouse Embryos
BiorXiv
DOI 10.1101/2025.04.25.650572
Article E-print Archive
2025
La Rosa L., Spattini C., Pelizzoli R., Pereira R., De Pietri Tonelli D.
A miRNA-based therapeutic approach for medulloblastoma in xenotransplanted wild-type mouse embryos
Neurogenomics Conference - Human Technopole - Milan (Italy) - May19th-21st
Poster Conference
2025
La Rosa L., Spattini C., Pereira R., De Pietri Tonelli D.
A miRNA-based therapy against Medulloblastoma validated in a Xenotransplanted model using wild-type mouse embryos
Neurogenomics Conference - Human Technopole - Milan (Italy) - May19th-21st
Poster Conference
2025
Perna A., Ribeiro J.F., Stubbendorff C., Orban G., Vincenzi M., Salemi E., Angotzi G.N., Fachechi L., Mastronardi V., Zapata S.C., Caltabiano A., Nava L., Gino A., Latella C., De Pietri Tonelli D., De Vittorio M., Pucci D., Tonini R., Berdondini L.
BRAINBOX: Biomechanical Research and AI-Integrated Neuroscience BOX
MNESYS – III Annual Meeting
Poster Conference
Vedi tutto
Awards and Achievements
2025
De Pietri tonelli D.
Certificate of Good Clinical Proctictice CH E6(R2)
2024
De Pietri Tonelli D.
Corresponding Member of the Accademia Ligure di Scienze e Lettere
2023
De Pietri Tonelli D.
Committee Member for the PhD evaluation of the course in "Biotecnologie in Medicina Traslazionale" XXXV ciclo – University of Genoa
2023
De Pietri Tonelli D.
Committee Member for the PhD evaluation of the course in "Neuroscience & Neurotechnologies" Ciclo XXXV – University of Genoa
2023
De Pietri Tonelli D.
Course on Human Subjects Research for Biomedical Research - Basic Course – Under requirements set by: NASA - National Aeronautics and Space Administration
Vedi tutto
Organized Events
2025
De Pietri Tonelli D.
Co-Organizer of the Philanthropic Dinner: "A cena con la Ricerca" in collaboration with Fondazione AIRC per la Ricerca sul Cancro
2025
De Pietri Tonelli D.
IIT Coordinator of the “RNA Collaborative Seminar Series” by the RNA society (USA)
2025
De Pietri Tonelli D.
Organizer of the symposium: "Connessioni e intrecci nella ricerca oncologica: Meccanismi, innovazioni tecnologiche e terapie" – Tavola rotonda con Andrea De Censi, Francesco Nicassio, Velia Siciliano, Marco Tagliamento. Modera Nicola Tirelli
2024
De Pietri Tonelli D., Gustincich S., Moretta L., Tirelli N.
Co-organiser of the workshop at the Science Festival in Genoa "Descrivere l'incurabile per poterlo sconfiggere"
2024
De Pietri Tonelli D.
Co-organizer of a fundraising event "A cena con la Ricerca" in collaboration with Fondazione AIRC per la Ricerca sul Cancro
Vedi tutto