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Giuseppe Vicidomini

Senior Researcher Tenure Track - Principal Investigator
Principal Investigator

Research Line

Molecular Microscopy and Spectroscopy

Center

IIT Central Research Lab Genova

Contacts

Via Morego, 30
+39 010 71781 976
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Social profiles

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About

Giuseppe Vicidomini studied computer science at the Department of Computer and Information Science, University of Genoa (DISI, Genoa, Italy) and received his Diploma in 2003. From 2003 to 2007 he worked at the Laboratory of Advance Microscopy and Spectroscopy (LAMBS, University of Genoa, Genoa, Italy); where he received his Ph.D (advised by Prof. Alberto Diaspro) about image processing and analysis for fluorescence microscopy. From 2008 to 2011 he worked as a post-doctoral fellow at the Department of NonoBiophotonics, Max Planck Institute for Biophysical Chemistry (MPI, Goettingen, Germany); where he developed a new approach to further enhance the resolution ability of stimulated emission deletion (STED) microscopy. Since May 2011 he works in the Department of NanoPhysics, Italian Institute of Technology (IIT, Genoa, Italy), where in September 2013 he obtained a Researcher position and in May 2016 he became principal investigator of the Molecular Microscopy and Spectroscopy research line. His research interests are primarily concentrated on theoretical design, development and validation of novel optical and analytical tools that allow the modern biologists to peer inside living biological systems with unprecedented temporal/spatial abilities and massive information content.

Bibliometric data:

Giuseppe Vicidomini has authored or co-authored 47 articles in peer reviewed international journals (10 as first author, 3 as shared first author, 1 as shared last author, and 12 as last author), 5 reviews in peer reviewed international journals, 15 proceedings in international conferences, 10 chapters in books and 1 editorial. He has given 17 invited talks at international conferences, advanced schools or workshops, 12 oral communications (as speaker) and 2 science cafés. He has filled 4 patents (two granted). 

Bibliometric data (source Scopus, July 2018): total 1476 citations (excluding self-citations), h-index 21.

Patents:

"Stimulated Emission-Depletion (STED) Microscopy Based on Time Gating of Excitation Beam and Synchronous Detection of Fluorescence Emission," WO/2015/022635

"STED Microscopy with Pulsed Excitation, Continuous Stimulation, and Gated Registration of Spontaneously Emitted Fluorescence Light,” WO/2012/069076 (licensed by Leica Microsystems, PicoQuant, Abberior Instruments)

Popular readings:

G. Vicidomini and G. Moneron, "Gated STED Microscopy with CW-STED Lasers: When the Arrival Time of a Photon Matters," Science Lab 

Interests

Super-Resolved Microscopy Time-Resolved Microscopy Single-Molecule

Projects

  • Observation of Biomolecular Processes in Live-Cell with Nanocamera, Fondazione San Paolo, Principal Investigator, 2018-2020;
  • AdaptiveSTED, H2020- MSCA-IF-2017, Supervisor (Fellowship applicant Dr Sami Koho), 2019- 2021;

Selected Publications

G. Vicidomini*, P. Bianchini, and A. Diaspro, "STED Super-Resolved Microscopy," Nat. Methods 15,173-182 (2018) (2018) DOI:10.1038/nmeth.4593

G. Tortarolo, M. Castello, A. Diaspro, S. Koho, G. Vicidomini*, "Evaluating Image Resolution in STED Microscopy," Optica 5(1), 32-35 (2018) DOI:10.1364/OPTICA.5.000032

L. Lanzano, L. Scippioni, M. DI Bona, P. Bianchini, R. Bizzarri, F. Cardarelli, A. Diaspro and G. Vicidomini*, "Measurement of nanoscale three-dimensional di usion in the interior of living cells by STED-FCS," Nat. Commun. 8(1), 65 (2017) DOI:10.1038/s41467-017-00117-2

L. Lanzano, I. Coto Hernandez, M. Castello, E. Gratton, A. Diaspro and G. Vicidomini*, "Encoding and decoding spatio-temporal information for super-resolution microscopy", Nat. Commun. 6, 6071 (2015) DOI:10.1038/ncomms7701

G. Vicidomini, G. Moneron, K.Y. Han, V. Westphal, H. Ta, M. Reuss, J. Engelhardt, C. Eggeling, S.W. Hell, “Sharper low-power STED nanoscopy by time gating”, Nat. Methods 8(7), 571-573 (2011) DOI:10.1038/NMETH.1624

Awards

Innovation Awards, SMARTcup Liguria 2016, category "industrial" (with Genoa Instruments)

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.