Globally aging populations and demographic changes will require new, innovative, and sympathetic approaches to all aspects of human life. Within this context, robotics and Artificial Intelligence (AI) have great potential to assist, augment, and empower humans. Advanced robots will not be confined to factories and manufacturing tasks. Rather, they will leave laboratories to help us in daily life. In addition AI-enabled robots will assist us in our personal lives (assistive technologies for the elderly and in healthcare), manage and improve safety in hazardous environments (safeguarding human life), and enhance medical treatment (improving quality of life). The Robotics Research Domain has five Priorities: Mechatronics, Soft Robotics, Social Cognition and Human Robot Interaction, Biomedical Robotics, and Intelligent Companion Robots. Some of these Priorities have a thematic character (Social Cognition and Human Robot Interaction, Intelligent Companion Robots), while others have a more technological nature (Mechatronics, Soft Robotics). However, they are all strongly focused on applications, often in connection with the other Research Domains (e.g., new materials for robotics, machine learning, biomedical applications).