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Luca Pandolfini

Researcher
Researcher
Non-coding RNAs and RNA-based therapeutics
Phone
+39 010 2897 623
Address
Via Enrico Melen 83, Building B 16152 Genova, Italy
Research center
CHT@Erzelli
Interests
Development
Neural Stem Cells
Planaria
Functional Genomics
RNA
About

Bio & Interests

I got my M.Sc. and Ph.D. in Scuola Normale Superiore di Pisa, Italy, then I moved to the UK to conduct my post-doctoral studies at the Gurdon Institute in Cambridge. Since 2020 I have been working as an independent researcher at Istituto Italiano di Tecnologia, Italy, focusing on nervous system development and regeneration. My lab strongly relies on multiple second- and third-generation sequencing approaches to dissect non-canonical model organisms from a developmental functional genomics point of view. 
In particular, I am committed to leveraging the power of long-read sequencing to understand the molecular mechanisms of (neuro)developmental processes of health and environmental interest.

Key Scientific Questions:

  1. How we can bolster developmental, evolutionary and conservation biology with third-generation genomics tools​
  2. What is the transcriptional foundation of neural regeneration, and how is it lost in higher vertebrates
Education

Title: PhD in Neurobiology
Institute: Scuola Normale Superiore di Pisa
Location: Pisa
Country: Italy
From: 2011 To: 2015

Title: Master’s degree in Molecular and Cell Biology
Institute: Scuola Normale Superiore di Pisa
Location: Pisa
Country: Italy
From: 2009 To: 2011

Experience External

Title: Research Associate
Institute: Gurdon Institute - University of Cambridge
Location: Cambridge
Country: United Kingdom
From: 2015 To: 2019

Top Publications
2023
Mangoni D., Simi A., Lau P., Armaos A., Ansaloni F., Codino A., Damiani D., Floreani L., Di Carlo V., Vozzi D., Persichetti F., Santoro C., Pandolfini L., Tartaglia G.G., Sanges R., Gustincich S.
LINE-1 regulates cortical development by acting as long non-coding RNAs
Nature Communications, vol. 14, (no. 1)
DOI 10.1038/s41467-023-40743-7
2023
Pierattini B., D'Agostino S., Bon C., Peruzzo O., Alendar A., Codino A., Ros G., Persichetti F., Sanges R., Carninci P., Santoro C., Espinoza S., Valentini P., Pandolfini L., Gustincich S.
SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides
Molecular Therapy - Nucleic Acids, vol. 32, pp. 402-414
DOI 10.1016/j.omtn.2023.04.002
2022
Dunville K., Tonelli F., Novelli E., Codino A., Massa V., Frontino A.M., Galfrè S., Biondi F., Gustincich S., Caleo M., Pandolfini L., Alia C., Cremisi F.
Laminin511 and WNT signalling sustain prolonged expansion of hiPSC-derived hippocampal progenitors.
Development (Cambridge)
DOI 10.1242/dev.200353
2022
Valentini P., Pierattini B., Zacco E., Mangoni D., Espinoza S., Webster N.A., Andrews B., Carninci P., Tartaglia G.G., Pandolfini L., Gustincich S.
Towards SINEUP-based therapeutics: Design of an in vitro synthesized SINEUP RNA
Molecular Therapy - Nucleic Acids, vol. 27, pp. 1092-1102
DOI 10.1016/j.omtn.2022.01.021
2021
Leger A., Amaral P.P., Pandolfini L., Capitanchik C., Capraro F., Miano V., Migliori V., Toolan-Kerr P., Sideri T., Enright A.J., Tzelepis K., van Werven F.J., Luscombe N.M., Barbieri I., Ule J., Fitzgerald T., Birney E., Leonardi T., Kouzarides T.
RNA modifications detection by comparative Nanopore direct RNA sequencing
Nature Communications, vol. 12, (no. 1)
DOI 10.1038/s41467-021-27393-3
All Publications
2024
Ivankovic M., Brand J.N., Pandolfini L., Brown T., Pippel M., Rozanski A., Grohme M.A., Winkler S., Schubert T., Robledillo L., Vila-Farré M., Zhang S., Gustincich S., Papantonis A., Marquez A., Rink J.C.
A comparative analysis of planarian genomes indicates regulatory conservation in the face of rapid structural divergence
Nature Communications, vol. 15, (no. 1), pp. 8215
DOI 10.1038/s41467-024-52380-9
Article Journal
2024
Gözde F., Landuzzi F., Brambilla A., Charrance D., Furia F., Trova S., Peracino A., Camenisch G., Waldvogel D., Howard-McCombe J., Spelorzi Y., Henzen E., Bernagozzi A., Coppe A., Christille J.M., Vecchi M., Vozzi D., Cavalli A., Bassano B., Gustincich S., Croll D., Pandolfini L., Grossen C.
A highly contiguous reference genome for the Alpine ibex (Capra ibex)
bioRxiv
Article Journal
2024
Mangoni D., Mazzetti A., Ansaloni F., Simi A., Tartaglia G.G., Pandolfini L., Gustincich S., Sanges R.
From the genome’s perspective: bearing somatic retrotransposition to leverage the regulatory potential of L1 RNAs
BioEssays
Review Journal
2023
D'Agostino S., Tettey M. A., Volpe M., Pierattini B., Ansaloni F., Lau P., Bon C., Peruzzo O., Braccia C., Armirotti A., Scarpato M., Damiani D., Di Carlo V., Carninci P., Santoro C., Persichetti F., Pandolfini L., Espinoza S., Zucchelli S., Sanges R., Gustincich S.
Internal Ribosome Entry Site RNAs act in trans through an antisense sequence in linear and circular non-coding RNAs
bioRxiv
DOI 10.1101/2023.05.25.542260
Article Journal
2023
Mangoni D., Simi A., Lau P., Armaos A., Ansaloni F., Codino A., Damiani D., Floreani F., Di Carlo V., Vozzi D., Persichetti F., Santoro C., Pandolfini L., Tartaglia G.G., Sanges R., Gustincich S.
L1 RNAs regulate cortical development by tuning PRC2 activity
EMBL Symposium: Brain genome: regulation, evolution and function
Poster Conference
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Dissemination
2023
Pandolfini L.
Neurogenesi e neoblasti in planaria
Frontiere della Biologia dello Sviluppo del Sistema Nervoso - Scuola Normale Superiore e Accademia dei Lincei - 5 Maggio 2023
Outreach
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Scientific Talks
2023
Pandolfini L., Cilingir G., Codino A., Castellano L., Pisano C., Castillo De Spelorzi YC., Henzen E., Vozzi D., Campigli Di Giammartino D., Gustincich S., Grossen C.
From genome assembly to epigenome characterisation: a nanopore journey in the footsteps of an endangered tortoise
ONT London Calling 2023 - May 18th-19th 2023
Conference
2023
Pandolfini L., Cilingir G., Codino A., Castellano L., Pisano C., Castillo De Spelorzi YC., Henzen E., Vozzi D., Campigli Di Giammartino D., Gustincich S., Grossen C.
Tortoise Conservation Genomics
Nanopore Day 2023 - Bologna 19th Sep 2023
Conference
2022
Codino A., La Rosa L., Pisano C., Gustincich S., Pandolfini L.
Pharmacological activation of Notch signalling pathway impairs head regeneration and locomotion in the asexual Schmidtea mediterranea
5th European Meeting on Planarian Biology - Sant Feliu de Guíxols - October 2nd –4th , 2022
Conference
2022
Pandolfini L., Rink J., Ivankovic M., Brand J., Rozanski A., Brochier T., Grohme M., Winkler S., Pippel M., Brown T., Marques A.
The new chromosome-scale S. mediterranea reference genome assembly and annotations—an update
5th European Meeting on Planarian Biology - Sant Feliu de Guíxols - October 2nd –4th , 2022
Conference
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Colleagues of Non-coding RNAs and RNA-based therapeutics
Martina Toscano Support Technician Non-coding RNAs and RNA-based therapeutics
Vittoria Perseghin Technician Non-coding RNAs and RNA-based therapeutics
Gloria Ros Post Doc Non-coding RNAs and RNA-based therapeutics
Luca Spagnoletti PhD Student Fellow Non-coding RNAs and RNA-based therapeutics
Antonio Amoroso Visiting Scientist Non-coding RNAs and RNA-based therapeutics
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